{"id":8,"date":"2024-09-12T16:42:54","date_gmt":"2024-09-12T14:42:54","guid":{"rendered":"http:\/\/wordpress.p677405.webspaceconfig.de\/?page_id=8"},"modified":"2024-10-31T12:21:52","modified_gmt":"2024-10-31T11:21:52","slug":"admeddicon-dmpk-consulting","status":"publish","type":"page","link":"https:\/\/admeddicon.com\/","title":{"rendered":"Admeddicon DMPK Consulting"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8\" class=\"elementor elementor-8\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0d7c18f e-con-full e-flex e-con e-parent\" data-id=\"0d7c18f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/admeddicon.com\\\/wp-content\\\/uploads\\\/2024\\\/09\\\/admeddicon-backgorund-video.mp4.mp4&quot;,&quot;background_play_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t<div class=\"elementor-background-video-container\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div><div class=\"elementor-element elementor-element-d1936b4 e-con-full e-flex e-con e-child\" data-id=\"d1936b4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-858c9a3 elementor-widget elementor-widget-spacer\" data-id=\"858c9a3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b44e7ab elementor-widget elementor-widget-heading\" data-id=\"b44e7ab\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Expert DMPK Consulting for Streamlined Drug Discovery and Development.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-075c3d9 elementor-widget elementor-widget-button\" data-id=\"075c3d9\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/#contact\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-17f1cc5 e-con-full e-flex e-con e-child\" data-id=\"17f1cc5\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ee4df2b elementor-widget elementor-widget-text-editor\" data-id=\"ee4df2b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span><b>ADMEDDICON \u2013 DMPK Consulting<\/b><\/span> is an independent preclinical consulting firm supporting biotech start-ups, university spin-offs and venture capitalists in bringing their assets from discovery into clinical stage development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7901a53 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"7901a53\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"\/#drug-developement\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 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class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 2600 131.1\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0 0L2600 0 2600 69.1 0 0z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.5\" d=\"M0 0L2600 0 2600 69.1 0 69.1z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.25\" d=\"M2600 0L0 0 0 130.1 2600 69.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 2600 131.1\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0 0L2600 0 2600 69.1 0 0z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.5\" d=\"M0 0L2600 0 2600 69.1 0 69.1z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.25\" d=\"M2600 0L0 0 0 130.1 2600 69.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c61ab76 e-con-full e-flex e-con e-child\" data-id=\"c61ab76\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d77d09d e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"d77d09d\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9b4f538 elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"9b4f538\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Partnering with you to overcome the challenges of drug development<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-780363c e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"780363c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInRight&quot;,&quot;animation_delay&quot;:600}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aea06db elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"aea06db\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Drug discovery<\/strong> without considering monetary constraints is already a challenge. When funding is limited, the definition of key questions, smart experimental design, and, if relevant, consideration of <strong>regulatory frameworks<\/strong> become critical aspects in achieving the next project milestone in a scientifically sound and <strong>cost-efficient<\/strong> manner.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9929df elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"d9929df\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>During the past <strong>25 years in Swiss pharma and biotech companies<\/strong>, I have helped bringing more than 50 drug candidates from lead discovery to <strong>clinical stage development<\/strong>, eight of which finally received marketing authorization and improve patients\u00b4 quality of life. ADMEDDICON thus has the expertise to <strong>support your projects<\/strong> with its proven scientific excellence, cost consciousness and regulatory experience.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2029e9c e-con-full e-flex e-con e-parent\" data-id=\"2029e9c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-59a11ce e-con-full e-flex e-con e-child\" data-id=\"59a11ce\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-e1ae430 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"e1ae430\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:600}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-118143f elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"118143f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The range of ADMEDDICON services covers <strong>all aspects of pharmacokinetic optimization and characterization<\/strong>, ranging from early lead profiling to candidate selection, PK\/PD correlations, formulation strategies for pharmacology and toxicology programs, first-in-human packages including toxicokinetics, drug-drug interaction strategies from in vitro data to clinical trials, metabolite safety assessments, and scientific consultancy for human ADME studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0c9b13e e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0c9b13e\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;animation_delay&quot;:900}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1449def elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"1449def\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>For questions outside its core competence, ADMEDDICON works with a <strong>network of qualified experts<\/strong> in the field of toxicology, regulatory, CMC, research informatics and early clinical development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63fb433 elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"63fb433\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I am a strong believer in <strong>interdisciplinary science<\/strong> and a lover of jazz music. Discovering drugs in fact has a lot in common with making music. It needs talented individuals that master their own instruments, but all equally need to listen to the sound of their neighbors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9828207 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"9828207\" data-element_type=\"container\" 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elementor-element-cf1ac7a e-con-full elementor-hidden-mobile e-flex e-con e-child\" data-id=\"cf1ac7a\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc04ca2 e-con-full e-flex e-con e-child\" data-id=\"dc04ca2\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-121c169 e-grid e-con-full e-con e-child\" data-id=\"121c169\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-076741b e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"076741b\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t<div class=\"elementor-element elementor-element-a8d1104 e-con-full e-flex e-con e-child\" data-id=\"a8d1104\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68bb88d elementor-widget__width-initial 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class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><\/g><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb7af43 elementor-widget elementor-widget-heading\" data-id=\"bb7af43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Strategic Consulting<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ebcf77 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"2ebcf77\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">DMPK strategies for lead optimization<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">DMPK strategies for and beyond IND-enabling programs<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Drug-drug interaction strategies (from test tube to clinical trial)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Strategic positioning for in- and outlicensing opportunities<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73b0465 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"73b0465\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:600}\">\n\t\t<div class=\"elementor-element elementor-element-07e9fa6 e-con-full e-flex e-con e-child\" data-id=\"07e9fa6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6197a04 elementor-widget__width-initial elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"6197a04\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"430\" height=\"430\" style=\"width:100%;height:100%;transform:translate3d(0,0,0)\" viewBox=\"0 0 430 430\"><defs><clipPath id=\"i\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"l\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"g\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"j\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"h\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><filter id=\"a\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><filter id=\"d\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><mask id=\"m\"><g filter=\"url(#a)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns1=\"http:\/\/www.w3.org\/1999\/xlink\" ns1:href=\"#c\"><\/use><\/g><\/mask><mask id=\"k\"><g filter=\"url(#d)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns2=\"http:\/\/www.w3.org\/1999\/xlink\" ns2:href=\"#f\"><\/use><\/g><\/mask><g id=\"c\" clip-path=\"url(#g)\" style=\"display:none\"><g style=\"display:none\"><path fill-opacity=\"0\" stroke-linecap=\"round\" stroke-linejoin=\"round\" class=\"primary\"><\/path><path><\/path><\/g><g style=\"display:none\"><path fill-opacity=\"0\" stroke-linecap=\"round\" stroke-linejoin=\"round\" class=\"primary\"><\/path><path><\/path><\/g><g style=\"display:none\"><path fill-opacity=\"0\" stroke-linecap=\"round\" stroke-linejoin=\"round\" class=\"primary\"><\/path><path><\/path><\/g><g style=\"display:none\"><path fill-opacity=\"0\" stroke-linecap=\"round\" stroke-linejoin=\"round\" class=\"primary\"><\/path><path><\/path><\/g><g style=\"display:none\"><path fill-opacity=\"0\" stroke-linecap=\"round\" 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stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"0\" d=\"M363 375.309h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12H363c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\"><\/path><path fill=\"red\" d=\"M363 375.309h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12H363c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\"><\/path><\/g><\/g><\/defs><g clip-path=\"url(#i)\"><g clip-path=\"url(#j)\" style=\"display:block\"><g mask=\"url(#k)\" style=\"display:block\"><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M326.573 342.502V136.086c0-25.624-20.773-46.396-46.397-46.396H149.12c-25.624 0-46.397 20.772-46.397 46.396v206.416\" class=\"secondary\"><\/path><\/g><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M36.406 34.809h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12h72.812c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\" style=\"display:block\" transform=\"translate(102.723 340.311)\"><\/path><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M36.406 34.809h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12h72.812c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\" style=\"display:block\" transform=\"translate(102.406 224.311)\"><\/path><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M36.406 34.809h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12h72.812c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\" style=\"display:block\" transform=\"translate(215.406 89.811)\"><\/path><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M36.406 34.809h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12h72.812c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\" style=\"display:block\" transform=\"translate(326.594 223.811)\"><\/path><path fill=\"none\" stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12.04\" d=\"M36.406 34.809h-72.812c-6.6 0-12-5.4-12-12v-45.618c0-6.6 5.4-12 12-12h72.812c6.6 0 12 5.4 12 12v45.618c0 6.6-5.4 12-12 12\" class=\"primary\" style=\"display:block\" transform=\"translate(326.594 340.5)\"><\/path><\/g><g clip-path=\"url(#l)\" style=\"display:none\"><g mask=\"url(#m)\" style=\"display:none\"><path fill=\"none\" class=\"secondary\"><\/path><\/g><path fill=\"none\" class=\"primary\" style=\"display:none\"><\/path><path fill=\"none\" class=\"primary\" style=\"display:none\"><\/path><path fill=\"none\" class=\"primary\" style=\"display:none\"><\/path><path fill=\"none\" class=\"primary\" style=\"display:none\"><\/path><path fill=\"none\" class=\"primary\" style=\"display:none\"><\/path><\/g><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cbb0283 elementor-widget elementor-widget-heading\" data-id=\"cbb0283\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scientific Consulting<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b9a75d elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"7b9a75d\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Design of lead optimization programs <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">DMPK trouble-shooting<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">PK\/PD analyses<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Bioanalytics<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Formulation strategies for pharmacology and toxicology<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Toxicokinetics <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Human ADME studies<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e795fae e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"e795fae\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:900}\">\n\t\t<div class=\"elementor-element elementor-element-821d1e3 e-con-full e-flex e-con e-child\" data-id=\"821d1e3\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10a0c71 elementor-widget__width-initial elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"10a0c71\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"430\" height=\"430\" style=\"width:100%;height:100%;transform:translate3d(0,0,0)\" viewBox=\"0 0 430 430\"><defs><clipPath id=\"i\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"l\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"f\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"j\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"h\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><filter id=\"a\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><filter id=\"c\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><mask id=\"m\"><g filter=\"url(#a)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns1=\"http:\/\/www.w3.org\/1999\/xlink\" ns1:href=\"#b\"><\/use><\/g><\/mask><mask id=\"k\"><g filter=\"url(#c)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use 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323.43c0-28.75 23.306-52.056 52.056-52.056s52.056 23.306 52.056 52.056-23.306 52.056-52.056 52.056-52.056-23.306-52.056-52.056\" class=\"secondary\"><\/path><path d=\"m374.663 279.645-56.57 56.57-18.87-18.87\" class=\"primary\"><\/path><\/g><\/g><g clip-path=\"url(#l)\" style=\"display:none\"><g mask=\"url(#m)\" style=\"display:none\"><path fill=\"none\" class=\"secondary\"><\/path><\/g><g fill=\"none\" style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><g fill=\"none\" style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><g fill=\"none\" style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><g fill=\"none\" style=\"display:none\"><path class=\"secondary\"><\/path><path class=\"primary\"><\/path><\/g><\/g><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a50e80 elementor-widget elementor-widget-heading\" data-id=\"9a50e80\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Operational Consulting<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46a649a elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"46a649a\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">DMPK project management<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">CRO selection<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">External study monitoring<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Interim management<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ef21222 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"ef21222\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:1500}\">\n\t\t<div class=\"elementor-element elementor-element-4bba7f1 e-con-full e-flex e-con e-child\" data-id=\"4bba7f1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c9b87d2 elementor-widget__width-initial elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"c9b87d2\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"430\" height=\"430\" style=\"width:100%;height:100%;transform:translate3d(0,0,0)\" viewBox=\"0 0 430 430\"><defs><clipPath id=\"h\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"v\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"w\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"t\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"u\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"o\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"q\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"p\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"i\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"n\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><clipPath id=\"j\"><path d=\"M0 0h430v430H0z\"><\/path><\/clipPath><mask id=\"x\"><use xmlns:ns1=\"http:\/\/www.w3.org\/1999\/xlink\" ns1:href=\"#a\"><\/use><\/mask><mask id=\"r\"><g filter=\"url(#b)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns2=\"http:\/\/www.w3.org\/1999\/xlink\" ns2:href=\"#c\"><\/use><\/g><\/mask><mask id=\"l\"><g filter=\"url(#d)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns3=\"http:\/\/www.w3.org\/1999\/xlink\" ns3:href=\"#e\"><\/use><\/g><\/mask><mask id=\"k\"><g filter=\"url(#f)\"><path fill=\"#fff\" d=\"M0 0h430v430H0z\" opacity=\"0\"><\/path><use xmlns:ns4=\"http:\/\/www.w3.org\/1999\/xlink\" ns4:href=\"#g\"><\/use><\/g><\/mask><filter id=\"b\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><filter id=\"d\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><filter id=\"f\" width=\"100%\" height=\"100%\" x=\"0%\" y=\"0%\" filterUnits=\"objectBoundingBox\"><\/filter><path id=\"a\" style=\"display:none\"><\/path><path id=\"c\" fill=\"red\" d=\"M26.69-186.57h.06v106.81h106.68v-.06z\" style=\"display:none\" transform=\"translate(214 214.76)\"><\/path><g id=\"e\" style=\"display:none\"><path fill-opacity=\"0\"><\/path><path><\/path><\/g><g id=\"g\" style=\"display:none\"><path fill-opacity=\"0\"><\/path><path><\/path><\/g><\/defs><g fill=\"none\" clip-path=\"url(#h)\"><g clip-path=\"url(#i)\" style=\"display:none\"><g clip-path=\"url(#j)\" mask=\"url(#k)\" style=\"display:none\"><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><\/g><g mask=\"url(#l)\" style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><g clip-path=\"url(#n)\" style=\"display:none\"><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><\/g><path class=\"primary\" style=\"display:none\"><\/path><g style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><path class=\"primary\" style=\"display:none\"><\/path><\/g><g stroke=\"#C6D21D\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"12\" clip-path=\"url(#o)\" style=\"display:block\"><g clip-path=\"url(#p)\" style=\"display:block\"><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 335.209)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 335.209)\"><\/path><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 268.209)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 268.209)\"><\/path><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 201.709)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 201.709)\"><\/path><\/g><g clip-path=\"url(#q)\" mask=\"url(#r)\" style=\"display:none\"><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 335.209)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 335.209)\"><\/path><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 268.209)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 268.209)\"><\/path><path d=\"M-46.998 0h93.996\" class=\"secondary\" style=\"display:block\" transform=\"translate(248.655 201.709)\"><\/path><path d=\"m-19.9.212 13.228 13.131 26.687-26.686\" class=\"secondary\" style=\"display:block\" transform=\"translate(154.955 201.709)\"><\/path><\/g><g style=\"display:block\"><path d=\"M241.69 28.19H81.57v373.14h266.86V134.94z\" class=\"primary\"><\/path><path d=\"M81.823 28.194v372.943h266.61\" class=\"primary\" opacity=\"0\"><\/path><\/g><path d=\"M-53.373-53.373V53.373H53.373\" class=\"primary\" style=\"display:block\" transform=\"translate(295.06 81.567)\"><\/path><\/g><g clip-path=\"url(#t)\" style=\"display:none\"><g clip-path=\"url(#u)\" style=\"display:none\"><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><\/g><path class=\"primary\" style=\"display:none\"><\/path><g style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><path class=\"primary\" style=\"display:none\"><\/path><\/g><g clip-path=\"url(#v)\" style=\"display:none\"><g clip-path=\"url(#w)\" mask=\"url(#x)\" style=\"display:none\"><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><path class=\"secondary\" style=\"display:none\"><\/path><\/g><path class=\"primary\" style=\"display:none\"><\/path><path class=\"primary\" style=\"display:none\"><\/path><g style=\"display:none\"><path class=\"primary\"><\/path><path class=\"primary\"><\/path><\/g><\/g><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aecf87 elementor-widget elementor-widget-heading\" data-id=\"9aecf87\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Regulatory Writing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-280ac3e elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"280ac3e\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Investigator\u00b4s Brochures<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Investigational New Drug Applications<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Scientific Advice Briefing Books<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-check-square\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm0 400H48V80h352v352zm-35.864-241.724L191.547 361.48c-4.705 4.667-12.303 4.637-16.97-.068l-90.781-91.516c-4.667-4.705-4.637-12.303.069-16.971l22.719-22.536c4.705-4.667 12.303-4.637 16.97.069l59.792 60.277 141.352-140.216c4.705-4.667 12.303-4.637 16.97.068l22.536 22.718c4.667 4.706 4.637 12.304-.068 16.971z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Regulatory Filings (US FDA, EMA, PMDA)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11e45ce e-con-full e-flex e-con e-parent\" data-id=\"11e45ce\" data-element_type=\"container\" id=\"profile\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-da7bb20 e-con-full e-flex e-con e-child\" data-id=\"da7bb20\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-31ccda7 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"31ccda7\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57bf16d elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"57bf16d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Profile<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f59d039 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"f59d039\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:600}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0ab23 elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"7a0ab23\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tI am an organic chemist by education but gradually moved away from synthetic chemistry during my PhD thesis looking into mechanisms of natural DNA damage and thus the molecular origin of evolution. As a postdoc, I worked on the metabolic activation of thiophene-containing drugs and their toxicity to the liver. This work opened the door to pharmaceutical industry which had just recognized the value of integrating pharmacokinetic and toxicological optimization early into the drug discovery process.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bccbe07 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"bccbe07\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;animation_delay&quot;:900}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9997c4e elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"9997c4e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>After four years at F. Hoffmann-La Roche AG in Basel as a drug metabolism scientist, I joined the newly created Actelion Pharmaceuticals Ltd to build a DMPK organization covering the entire process from lead optimization up to regulatory filing. In 2017, Actelion was acquired by Johnson &amp; Johnson for 30 billion USD, and the research and early development units were transferred into a new company, Idorsia Pharmaceuticals Ltd. I was part of its research management team and thus co-responsible for the strategic, scientific and organizational management of a 35-project pipeline.<\/p><p><br \/>Early in 2024, I founded ADMEDDICON \u2013 DMPK Consulting, an independent preclinical consulting firm with the idea to share my strategic and scientific experience in collaborations with biotech companies, university spin-offs and venture capital firms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8a472ca e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"8a472ca\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_scale_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_scale_direction&quot;:&quot;in-out&quot;,&quot;background_motion_fx_scale_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:2,&quot;sizes&quot;:[]},&quot;shape_divider_top&quot;:&quot;opacity-tilt&quot;,&quot;shape_divider_bottom&quot;:&quot;opacity-tilt&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;animation&quot;:&quot;fadeIn&quot;,&quot;background_motion_fx_scale_range&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:20,&quot;end&quot;:80}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 2600 131.1\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0 0L2600 0 2600 69.1 0 0z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.5\" d=\"M0 0L2600 0 2600 69.1 0 69.1z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.25\" d=\"M2600 0L0 0 0 130.1 2600 69.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 2600 131.1\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0 0L2600 0 2600 69.1 0 0z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.5\" d=\"M0 0L2600 0 2600 69.1 0 69.1z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.25\" d=\"M2600 0L0 0 0 130.1 2600 69.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-58824b1 e-con-full e-flex e-con e-parent\" data-id=\"58824b1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fab4fb9 e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"fab4fb9\" data-element_type=\"widget\" data-settings=\"{&quot;tabs_justify_horizontal&quot;:&quot;start&quot;,&quot;horizontal_scroll&quot;:&quot;disable&quot;}\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"262885305\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-2628853051\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-2628853051\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tPrevious Positions\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-2628853052\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-2628853052\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tEducation\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"publications\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-2628853053\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tPublications\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-2628853051\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-2628853051\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-a9d2cfc e-con-full e-flex e-con e-child\" data-id=\"a9d2cfc\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cd241e1 e-con-full e-flex e-con e-child\" data-id=\"cd241e1\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-28db013 e-con-full e-flex e-con e-child\" data-id=\"28db013\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-64d98a7 elementor-widget elementor-widget-text-editor\" data-id=\"64d98a7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1996-2000<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-027083d e-con-full e-flex e-con e-child\" data-id=\"027083d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a626fa6 elementor-widget elementor-widget-text-editor\" data-id=\"a626fa6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Laboratory Head, Preclinical Drug Metabolism, F. Hoffmann \u2013 La Roche AG, Basel<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-168c1e7 e-con-full e-flex e-con e-child\" data-id=\"168c1e7\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-b412190 e-con-full e-flex e-con e-child\" data-id=\"b412190\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-233364d elementor-widget elementor-widget-text-editor\" data-id=\"233364d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t2000-2004\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f5caf5c e-con-full e-flex e-con e-child\" data-id=\"f5caf5c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d61d85 elementor-widget elementor-widget-text-editor\" data-id=\"4d61d85\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDirector, Head Nonclinical DMPK, Actelion Pharmaceuticals Ltd, Allschwil\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c93705 e-con-full e-flex e-con e-child\" data-id=\"3c93705\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4d0fc6d e-con-full e-flex e-con e-child\" data-id=\"4d0fc6d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2e7107 elementor-widget elementor-widget-text-editor\" data-id=\"e2e7107\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>2004-2009<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ecd24bf e-con-full e-flex e-con e-child\" data-id=\"ecd24bf\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4690eb3 elementor-widget elementor-widget-text-editor\" data-id=\"4690eb3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tSenior Director, Head Nonclinical DMPK, Actelion Pharmaceuticals Ltd\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a5891fe e-con-full e-flex e-con e-child\" data-id=\"a5891fe\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-31c51ff e-con-full e-flex e-con e-child\" data-id=\"31c51ff\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9bb401d elementor-widget elementor-widget-text-editor\" data-id=\"9bb401d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>2009-2017<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5bae533 e-con-full e-flex e-con e-child\" data-id=\"5bae533\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adaf65e elementor-widget elementor-widget-text-editor\" data-id=\"adaf65e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tVice President, Head Nonclinical DMPK, Actelion Pharmaceuticals Ltd\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-222797e e-con-full e-flex e-con e-child\" data-id=\"222797e\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-0d6d16c e-con-full e-flex e-con e-child\" data-id=\"0d6d16c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6521e5 elementor-widget elementor-widget-text-editor\" data-id=\"d6521e5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t2017-2023\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1336557 e-con-full e-flex e-con e-child\" data-id=\"1336557\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4eda1ae elementor-widget elementor-widget-text-editor\" data-id=\"4eda1ae\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tVice President, Head Nonclinical DMPK, Idorsia Pharmaceuticals Ltd, Allschwil\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ebacb68 e-con-full e-flex e-con e-child\" data-id=\"ebacb68\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5a7e549 e-con-full e-flex e-con e-child\" data-id=\"5a7e549\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e8b9fb3 elementor-widget elementor-widget-text-editor\" data-id=\"e8b9fb3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t2011-2023\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-187aa53 e-con-full e-flex e-con e-child\" data-id=\"187aa53\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca5ec79 elementor-widget elementor-widget-text-editor\" data-id=\"ca5ec79\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDeputy Head Nonclinical Development, Actelion and Idorsia Pharmaceuticals Ltd\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-90fd0d5 e-con-full e-flex e-con e-child\" data-id=\"90fd0d5\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8d3e467 e-con-full e-flex e-con e-child\" data-id=\"8d3e467\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83fb078 elementor-widget elementor-widget-text-editor\" data-id=\"83fb078\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t2024\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-039376e e-con-full e-flex e-con e-child\" data-id=\"039376e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15aca33 elementor-widget elementor-widget-text-editor\" data-id=\"15aca33\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tFounder and Managing Director ADMEDDICON \u2013 DMPK Consulting\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-2628853052\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-2628853052\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-ea8dba3 e-con-full e-flex e-con e-child\" data-id=\"ea8dba3\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-41d6361 e-con-full e-flex e-con e-child\" data-id=\"41d6361\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8abc888 e-con-full e-flex e-con e-child\" data-id=\"8abc888\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f85c80 elementor-widget elementor-widget-text-editor\" data-id=\"3f85c80\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1984-1990<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c28dd33 e-con-full e-flex e-con e-child\" data-id=\"c28dd33\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77f05f7 elementor-widget elementor-widget-text-editor\" data-id=\"77f05f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tChemistry studies at the universities of Heidelberg (Germany) and Bristol (UK). Diploma thesis on rearrangement reactions of substituted triarylamines; awarded with a grant of the Dr. Sophie-von-Bernthsen fond. Fellow of Studienstiftung des Deutschen Volkes and Deutscher Akademischer Austauschdienst.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a7635e5 e-con-full e-flex e-con e-child\" data-id=\"a7635e5\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d68747b e-con-full e-flex e-con e-child\" data-id=\"d68747b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-23111a0 elementor-widget elementor-widget-text-editor\" data-id=\"23111a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1991-1994<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7218552 e-con-full e-flex e-con e-child\" data-id=\"7218552\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fd1c9cf elementor-widget elementor-widget-text-editor\" data-id=\"fd1c9cf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tUniversity of W\u00fcrzburg, Germany, PhD thesis on mechanisms of DNA damage by natural peroxides.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2e335a e-con-full e-flex e-con e-child\" data-id=\"c2e335a\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5c5bcf9 e-con-full e-flex e-con e-child\" data-id=\"5c5bcf9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d13d2b5 elementor-widget elementor-widget-text-editor\" data-id=\"d13d2b5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1995-1996<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2a69c95 e-con-full e-flex e-con e-child\" data-id=\"2a69c95\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fc71425 elementor-widget elementor-widget-text-editor\" data-id=\"fc71425\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tCentre National de la Recherche Scientifique, Paris, France, Postdoctoral stage on drug-induced liver toxicity of thiophene-containing drugs. Fellow of the Deutsche Forschungsgemeinschaft.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-2628853053\" role=\"tabpanel\" aria-labelledby=\"publications\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-21c56c7 e-con-full e-flex e-con e-child\" data-id=\"21c56c7\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-a6f8edf e-con-full e-flex e-con e-child\" data-id=\"a6f8edf\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cfce9b9 e-con-full e-flex e-con e-child\" data-id=\"cfce9b9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-555bac4 elementor-widget elementor-widget-text-editor\" data-id=\"555bac4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Treiber, S. Seeland, B. Hashimi, J. Williams, H. Aissauoi. The metabolism of the selective orexin 1 receptor antagonist nivasorexant. <em>Xenobiotica<\/em>, <strong>2024<\/strong>, <em>54, <\/em>124-137<em>. <\/em><a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Nivasorexant-metabolism_Xenobiotica-2024.pdf\" target=\"_blank\" rel=\"noopener\"><strong>(Download PDF)<\/strong><\/a><\/li><\/ol><ol start=\"2\"><li>Treiber, S. Seeland, J. Segrestaa, C. Lescop, M. H. Bolli. Reversible oxidation\/reduction steps in the metabolic degradation of the glycerol side chain of the S1P<sub>1<\/sub> agonist ponesimod. <em>Xenobiotica<\/em>, <strong>2024<\/strong>, <em>54, <\/em>182-194<em>. <\/em><a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Ponesimod-metabolism_Xenobiotica-2024.pdf\" target=\"_blank\" rel=\"noopener\"><strong>(Download PDF)<\/strong><\/a><\/li><\/ol><ol start=\"3\"><li>A. Steiner, L. Botticelli, G. Bergamini, E. Micioni di Bonaventura, J. Gatfield, J. Williams, A. Treiber, C. Vaillant, C. Cifani, M. V. Micioni di Bonaventura. Evaluation of the selective orexin receptor antagonist nivasorexant in an animal model of binge eating disorder, <em>J Eat Disorders<\/em>, <strong>2024<\/strong>, doi: 10.1002\/eat.24181. PMID: 38456603.<\/li><\/ol><ol start=\"4\"><li>T. Williams, M. H. Bolli, C. Brotschi, C. Roch, T. Sifferlen, M. A. Steiner, A. Treiber, J. Gatfield, C. Boss. Discovery of nivasorexant (ACT-539313): The first selective orexin-1-receptor antagonist (SO1RA) investigated in clinical trials. <em>J. Med. Chem.<\/em>, <strong>2024<\/strong>, <em>67, <\/em>344-354.<\/li><\/ol><ol start=\"5\"><li>Brotschi, M. H. Bolli, J. Gatfield, C. Roch, T. Sifferlen, A. Treiber, J. T. Williams, C. Boss. Pyrazole derivatives as selective orexin-2 antagonists (2-SORA): synthesis, structure-activity relationship, and sleep-promoting properties in rats. <em>Royal Soc. Chem. Med Chem. J.<\/em>, <strong>2024<\/strong>, 15, 334-354.<\/li><\/ol><ol start=\"6\"><li>Berger, P. Kaufmann, M. Berse, A. Treiber, N. Grignaschi, J. Dingemanse. Effect of nivasorexant (ACT\u2011539313), a selective orexin-1 receptor antagonist, on multiple cytochrome P450 probe substrates in vitro and in vivo using a cocktail approach in healthy subjects. <em>Pharmacol. Res. Perspect.<\/em>, <strong>2023<\/strong>, 11:201143, DOI:10.1002\/prp2.1143<em>.<\/em><\/li><\/ol><ol start=\"7\"><li>Treiber, H. Aissaoui, S. Delahaye, S. Glutz, J. Grimont, C. M\u00fcller, S. Seeland, V. Siefken, C. Boss. CYP3A4 catalyzes the rearrangement of the dual orexin receptor antagonist daridorexant to 4-hydroxy piperidinol metabolites. <em>Chem. Med. Chem.<\/em>, <strong>2023,<\/strong> <em>18<\/em>, e202300030, DOI:10.1002\/cmdc.202300030.\u00a0<a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Daridorexant-rearrangement-by-CYP3A4_ChemMedChem-2023.pdf\" target=\"_blank\" rel=\"noopener\"><strong>(Download PDF)<\/strong><\/a><\/li><\/ol><ol start=\"8\"><li>Treiber, S. Delahaye A. Weigel, P. Ae\u00e4nismaa, J. Gatfield, S. Seeland. The metabolism of the dual orexin receptor antagonist daridorexant. <em>Xenobiotica<\/em>, <strong>2023<\/strong>, <em>53<\/em>, 173-183.<\/li><\/ol><ol start=\"9\"><li>Treiber and M. H. Bolli. The bile salt export pump BSEP, in The Medicinal Chemist&#8217;s Guide to Solving ADMET Challenges (ed. P. Schnider), Royal Society of Chemistry, <strong>2021<\/strong>, chapter 8, 160-171<em>.<\/em><\/li><\/ol><ol start=\"10\"><li>Boss, J. Gatfield, C. Brotschi, B. Heidmann, T. Sifferlen, M. von Raumer, G. Schmidt, J.T. Williams, A. Treiber, C. Roch. The quest for the best dual orexin receptor antagonist (daridorexant) for the treatment of insomnia disorders. <em>Chem. Med. Chem.<\/em>, <strong>2020<\/strong>, <em>15<\/em>, 2286-2305.<\/li><\/ol><ol start=\"11\"><li>Treiber, S. Delahaye, S. Seeland, C. Gnerre. The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: a cross-species comparison of its cytochrome P450 induction pattern. <em>Pharmacol. Res. Perspect<\/em>, <strong>2020<\/strong>,<em> 00:e00619; https:\/\/doi.org\/ 10.1002\/prp2.619. <\/em><strong><a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Macitentan-cross-species-comparison-P450-induction_PRP-2020.pdf\" target=\"_blank\" rel=\"noopener\">(Download PDF)<\/a><\/strong><\/li><\/ol><ol start=\"12\"><li>Brotschi, M.H. Bolli, J. Gatfield, B. Heidmann, F. Jenck, C. Roch, T. Sifferlen, A. Treiber, J. T. Williams, C. Boss. From oxadiazole to triazole analogues: optimization towards a dual orexin receptor antagonist with improved in vivo efficacy in dogs. <em>Chem. Med. Chem, <\/em><strong>2020<\/strong><em>, 15, <\/em>1-20.<\/li><\/ol><ol start=\"13\"><li>Brotschi, C. Roch, J. Gatfield, A. Treiber, J. T. Williams, T. Sifferlen, B. Heidmann, F. Jenck, M.H. Bolli, C. Boss. Oxadiazole derivatives as dual orexin receptor antagonists: synthesis, structure-activity relationship, and sleep-promoting properties in rat. <em>Chem. Med. Chem, <\/em><strong>2019<\/strong><em>, 14, <\/em>1257-1270.<\/li><\/ol><ol start=\"14\"><li>Ichikawa, T. Yamada, A. Treiber, C. Gnerre, J. Segrestaa, S. Seeland, K. Nonaka. Cross-species comparison of the metabolism and excretion of selexipag. <em>Xenobiotica, <\/em><strong>2019<\/strong><em>, 49, <\/em>284-301.<\/li><\/ol><ol start=\"15\"><li>Ichikawa, T. Yamada, K. Nonaka, A. Treiber, C. Gnerre, K. Seya, S. Ochi. Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs, and monkeys. <em>Xenobiotica, <\/em><strong>2018<\/strong><em>, 48, <\/em>186-196.<\/li><\/ol><ol start=\"16\"><li>Gnerre, J. Segrestaa, S. Seeland, P. Ae\u00e4nismaa, T. Pfeifer, S. Delahaye, R. de Kanter, T. Ichikawa, T. Yamada, A. Treiber. The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag. <em>Xenobiotica<\/em>, <strong>2017<\/strong>, <em>Aug 30, 1-16.<\/em><\/li><\/ol><ol start=\"17\"><li>Treiber, R. de Kanter, C. Roch, J. Gatfield, C. Boss, M. von Raumer, B. Schindelholz, C. M\u00fchlan, J. van Gerven, F. Jenck. The use of PBPK modeling in the discovery of the dual orexin antagonist ACT-541468. <em>J. Pharmacol. Exp. Ther., <\/em><strong>2017<\/strong><em>, <\/em><em>362,<\/em>489-503<em>. <\/em><a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/JPET-paper-as-published-2017-08-22.pdf\" target=\"_blank\" rel=\"noopener\"><strong>(Download PDF)<\/strong><\/a><\/li><\/ol><ol start=\"18\"><li>H. Bolli, C. Boss, A. Treiber, J. Gatfield. The discovery of macitentan &#8211; A standard medicinal discovery program? In: S. Chackalamannil, D. P. Rotella and S. E. Ward (eds.). <em>Comprehensive Medicinal Chemistry III<\/em>, <strong>2017<\/strong>, vol. 8, 252-283.<\/li><\/ol><ol start=\"19\"><li>Heidmann, J. Gatfield, C. Roch, A. Treiber, S. Tortoioli, C. Brotschi, J. T. Williams, M. H. Bolli, T. Sifferlen, F. Jenck, C. Boss. Discovery of highly potent dual orexin receptor antagonists via a scaffold hopping approach. <em>Chem. Med. Chem<\/em>, <strong>2016<\/strong>, <em>11, <\/em>2132-2146<em>.<\/em><\/li><\/ol><ol start=\"20\"><li>de Kanter, P. Sidharta, S. Delahaye, C. Gnerre, J. Segrestaa, S. Buchmann, C. Kohl, A. Treiber. Physiologically-based pharmacokinetic (PBPK) modeling of macitentan: prediction of drug-drug interactions<em>. Clin. Pharmacokin.<\/em>, <strong>2016<\/strong>, 55, 369-380<em>.<\/em><\/li><\/ol><ol start=\"21\"><li>Caroff, F. Hubler, E. Meyer, D. Renneberg, A. Treiber, M. Rey, P. Hess, B. Steiner, K. Hilpert, M. A. Riederer. 4-((<em>R<\/em>)-2-{[6-((<em>S<\/em>)-3-Methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester (ACT\u2011246475), a novel P2Y<sub>12<\/sub> receptor antagonist with an improved in vivo efficacy\/safety ratio.<em> J. Med. Chem.,<\/em> <strong>2015<\/strong>, <em>58, <\/em>9133-9153<em>.<\/em><\/li><\/ol><ol start=\"22\"><li>Treiber, T. Miraval, M. H. Bolli, J.-A. Funel, J. Segrestaa, S. Seeland. The metabolism of the dual endothelin receptor antagonist macitentan in the rat and dog. <em>Xenobiotica.<\/em>, <strong>2015<\/strong>,<em> 4<\/em>, 1-15<em>.<\/em><\/li><\/ol><ol start=\"23\"><li>T. Williams, J. Gatfield, C. Roch, A. Treiber, F. Jenck, M. H. Bolli, T. Sifferlen, B. Heidmann, C. Boss. Discovery and optimization of 2-benzyl pyrrolidine carboxamides as potent dual orexin antagonists. <em>Chem Med Comm<\/em>, <strong>2015<\/strong>, <em>6, <\/em>1054-1064.<\/li><\/ol><ol start=\"24\"><li>Sifferlen, A. Boller, A. Chardonneau, E. Cottreel, J. Gatfield, A. Treiber, C. Roch, F. Jenck, H. Aissaoui, J. T. Williams, C. Brotschi, B. Heidmann, R. Siegrist and C. Boss. Substituted pyrrolidin-2ones: Centrally acting orexin receptor antagonist promoting sleep. <em>Bioorg. Med. Chem. Lett.,<\/em> <strong>2015<\/strong>, <em>25,<\/em> 1884-1891.<\/li><\/ol><ol start=\"25\"><li>N. Sidharta, A. Treiber, J. Dingemanse. Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan: A systematic review. <em>Clin. Pharmacokin. <\/em><strong>2015<\/strong>, <em>54,<\/em> 457-471.<\/li><\/ol><ol start=\"26\"><li>Seeland, H. Kettiger, M. Murphy, A. Treiber, J. Giller, A. Kiss, R. Sube, S. Kr\u00e4henb\u00fchl, M. Hafner, J. Huwyler. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. <em>Pharmacol. Res. Perspectives<\/em>, <strong>2015<\/strong>, <em>3, e00123.<\/em><\/li><\/ol><ol start=\"27\"><li>Gehin, P. N. Sidharta, C. Gnerre, A. Treiber, A. Halabi, J. Dingemanse. Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist. <em>Eur. J. Clin. Pharmacol.<\/em>, <strong>2015<\/strong>, <em>71<\/em>. 15-23.<\/li><\/ol><ol start=\"28\"><li>Boss, C. Roch-Brisbare, A. Treiber, M. A. Steiner, F. Jenck, M. von Raumer, T. Sifferlen, C. Brotschi, M. Bolli, B. Heidmann, J. Williams, H. Aissaoui, R. Siegrist and J. Gatfield. Structure-activity relationship, biological and pharmacological characterization of the proline sulfonamide ACT-462206, a highly potent, brain-penetrant dual orexin 1\/ orexin 2 receptor antagonist. <em>Chem Med Chem<\/em>, <strong>2014<\/strong>, <em>9. <\/em>2486-2496.<\/li><\/ol><ol start=\"29\"><li>Caroff, E. Meyer, A. Treiber, K. Hilpert, M. Riederer. Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable, and selective P2Y<sub>12<\/sub> antagonists for inhibition of platelet aggregation.<em> Bioorganic &amp; Medicinal Chemistry Letters<\/em> <strong>2014<\/strong>, <em>24, <\/em>4323-4331<em>.<\/em><\/li><\/ol><ol start=\"30\"><li>Treiber, P. A\u00e4nismaa, R. de Kanter, S. Delahaye, M. Treher, P. Hess, P. Sidharta. Macitentan does not interfere with hepatic bile salt transport. <em>J. Pharm. Exp. Ther.<\/em> <strong>2014<\/strong>, <em>350, <\/em>130-143. <a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Macitentan-and-BSEP-inhibition_JPET-2014.pdf\" target=\"_blank\" rel=\"noopener\"><strong>(Download PDF)<\/strong><\/a><\/li><\/ol><ol start=\"31\"><li>Sifferlen, A. Boller, A. Chardonneau, E. Cottreel, J. H\u00f6cker, H. Aissoui, J. T. Williams, B. Heidmann, R. Siegrist, T. Weller, J. Gatfield, A. Treiber, C. Brisbare-Roch, F. Jenck, C. Boss. Discovery of substituted lactams as novel, dual orexin receptor antagonists. Synthesis, preliminary structure activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part I. <em>Bioorg. Med. Chem. Lett.<\/em>, <strong>2014<\/strong>, <em>24, <\/em>1201-1208.<\/li><\/ol><ol start=\"32\"><li>H. Bolli, C. M\u00fcller, B. Mathys, S. Abele, M. Birker, R. Bravo, D. Bur, C. Kohl, D. Lehmann, O. Nayler, M. Rey, S. Meyer, M. Scherz, G. Schmidt, B. Steiner, A. Treiber, J. Velker, T. Weller. Novel S1P<sub>1<\/sub> receptor agonists \u2013 Part 1: From pyrazoles to thiophenes. <em>J. Med. Chem<\/em>.<strong>2013<\/strong>, <em>56, <\/em>9737-9755.<\/li><\/ol><ol start=\"33\"><li>A. Steiner, J. Gatfield, C. Brisbare-Roch, H. Dietrich, F. Jenck, A. Treiber, F. Jenck, C. Boss. Discovery and characterization of ACT-335827, an orally available, brain-penetrant orexin receptor type-1 selective antagonist. <em>J. Med. Chem.<\/em>, <strong>2013<\/strong>, <em>8<\/em>, 898-903.<\/li><\/ol><ol start=\"34\"><li>Seeland, M. T\u00f6r\u00f6k, H. Kettiger, A. Treiber, M. Hafner, J. Huwyler. A cell-based, multi-parametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells. <em>Toxicology in vitro <\/em><strong>2013<\/strong>, <em>27,<\/em> 1109-1120.<\/li><\/ol><ol start=\"35\"><li>Dingemanse, A. Treiber, K. Shakeri-Nejad, G. Hopfgartner, P. Hoever. Elucidation of the metabolic pathways and the resulting multiple metabolites of almorexant, a dual orexin receptor antagonist, in humans. <em>Drug Metab. Dispos. <\/em><strong>2013<\/strong>, <em>41<\/em>, 1046-1059.<\/li><\/ol><ol start=\"36\"><li>Fahrmayr, J. K\u00f6nig, D. Auge, M. Mieth, J. Segrestaa, T. Pfeifer, A. Treiber, M. F. Fromm. Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line. <em>Br. J.<\/em> <em>Pharmacol.<\/em> <strong>2013<\/strong>, <em>169, <\/em>21-33<em>.<\/em><\/li><\/ol><ol start=\"37\"><li>H. Bolli, C. Boss, C. Binkert, S. Buchmann. D. Bur, P. Hess, M. Iglarz, S. Meyer, J. Rein, M. Rey, A. Treiber, M. Clozel, W. Fischli, T. Weller. The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N&#8217;-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist. <em>J. Med. Chem.<\/em> <strong>2012<\/strong>, 55, 7849-7861.<\/li><\/ol><ol start=\"38\"><li>Bruderer, G. Hopfgartner, M. Seiberling, J. Wank, A. Treiber, J. Dingemanse<sup>. <\/sup>Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans. <em>Xenobiotica<\/em>, <strong>2012<\/strong>, <em>14, <\/em>901-910.<\/li><\/ol><ol start=\"39\"><li>Bruderer, P. Ae\u00e4nismaa, M.C. Homery, S. H\u00e4usler, K. Landskroner, P. Sidharta, A. Treiber, J. Dingemanse. Effect of cyclosporine A and rifampicin on the pharmacokinetics of macitentan, a tissue-targeting endothelin receptor antagonist. <em>AAPS J.<\/em> <strong>2012, <\/strong>68-78.<\/li><\/ol><ol start=\"40\"><li>Seeland, A. Treiber, M. Hafner, J. Huwyler. On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells. <em>Biochim. Biophys. Acta \u2013 Biomembranes <\/em><strong>2011, <\/strong><em>1808<\/em><strong>, <\/strong>1827-1831.<\/li><\/ol><ol start=\"41\"><li>Landskroner, P. Hess, A. Treiber. Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics, <em>Xenobiotica<\/em> <strong>2011<\/strong>, <em>48<\/em>, 687-700.<\/li><\/ol><ol start=\"42\"><li>Corminboeuf, O. Bezencon, L. Remen, C. Grisostomi, S. Richard-Bildstein, D. Bur, L Prade, P. Strickner, P. Hess, W. Fischli, B. Steiner, A. Treiber. Piperidine-based renin inhibitors: upper chain optimization. <em>Bioorg. Med. Chem. <\/em><em>Lett.<\/em> <strong>2010<\/strong>, <em>20<\/em>, 6291-6296.<\/li><\/ol><ol start=\"43\"><li>Corminboeuf, O. Bezencon, C. Grisostomi, L. Remen, S. Richard-Bildstein, D. Bur, L Prade, P. Hess, P. Strickner, W. Fischli, B. Steiner, A. Treiber. Design and optimization of new piperidines as renin inhibitors. <em>Bioorg. Med. Chem. <\/em><em>Lett.<\/em> <strong>2010<\/strong>, <em>20<\/em>, 6286-6290.<\/li><\/ol><ol start=\"44\"><li>H. Bolli, S. Abele, C. Binkert, R. Bravo, S. Buchmann, D. Bur, J. Gatfield, P. Hess, C. Kohl, C. Mangold, B. Mathys, K. Menyhart, C. M\u00fcller, O. Nayler, M. Scherz, G. Schmidt, V. Sippel, B. Steiner, D. Strasser, A. Treiber, T. Weller. 2-Imino-thiazolidin-4-one derivatives as potent, orally active S1P<sub>1<\/sub> receptor agonists. <em>J. Med. Chem.<\/em> <strong>2010<\/strong>, <em>53<\/em>, 4198\u20134211<\/li><\/ol><ol start=\"45\"><li>Remen, O. Bezen\u00e7on, S. Richard-Bildstein, D. Bur, L. Prade, O. Corminboeuf, C. Boss, C. Grisostomi, T. Sifferlen, P. Strickner, P. Hess, S. Delahaye, A. Treiber, T. Weller, C. Binkert, B. Steiner, W. Fischli. New classes of potent and bioavailable human renin inhibitors. <em>Bioorg. Med. Chem. Lett<\/em>., <strong>2009<\/strong>, <em>19<\/em>, 6762-6765.<\/li><\/ol><ol start=\"46\"><li>Bezen\u00e7on, D. Bur, T. Weller, S. Richard-Bildstein, L. Remen, T. Sifferlen, O. Corminboeuf, C. Grisostomi, L. Prade, S. Delahaye, A. Treiber, P. Strickner, P. Hess, B. Steiner, and W. Fischli. Design and preparation of potent, non-peptidic, bioavailable renin inhibitors. <em>J. Med. Chem., <\/em><strong>2009<\/strong><em>, 52, <\/em>3689-3702<em>.<\/em><\/li><\/ol><ol start=\"47\"><li>L.M. van Giersbergen, A. Treiber, J. Dingemanse. In vitro and in vivo pharmacokinetic characteristics of clazosentan, an intravenous endothelin receptor antagonist, in humans, <em>Int. J. Clin. Pharm. Ther.<\/em><strong> 2009<\/strong>, <em>47, <\/em>169-177<em>.<\/em><\/li><\/ol><ol start=\"48\"><li>Aissaoui, R. Koberstein, C. Zumbrunn, J. Gatfield, C. Brisbare-Roch, F. Jenck, A. Treiber, C. Boss. N-Glycine-sulfonamides as potent dual orexin-1\/orexin-2 receptor antagonists. <em>Bioorg. Me.l Chem. Lett. <\/em><strong>2008<\/strong>, <em>18, <\/em>5729-5733<em>.<\/em><\/li><\/ol><ol start=\"49\"><li>Iglarz, C. Binkert, K. Morrison, W. Fischli, J. Gatfield, A. Treiber, T. Weller, M.H. Bolli, C. Boss, S. Buchmann, B. Capeleto, P. Hess, C. Qiu, M. Clozel. Pharmacology of macitentan, an orally active, tissue-targeting dual endothelin receptor antagonist. <em>J. Pharm. Exp. Ther. <\/em><strong>2008<\/strong>, <em>327<\/em>, 736-745.<\/li><\/ol><ol start=\"50\"><li>Treiber, O. Morand, M. Clozel. The pharmacokinetics and tissue distribution of miglustat in the rat, <em>Xenobiotica <\/em><strong>2007<\/strong>, <em>37, <\/em>298-314<em>.<\/em><\/li><\/ol><ol start=\"51\"><li>Treiber, R. Schneiter, S. H\u00e4ussler, B. Stieger. Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin and sildenafil<em>, Drug Metab. Dispos. <\/em><strong>2007<\/strong>, <em>35<\/em>, 1400-1408. <strong><a href=\"http:\/\/wordpress.p677405.webspaceconfig.de\/wp-content\/uploads\/2024\/10\/Bosentan-is-a-OATP-substrate_DMD-2007.pdf\" target=\"_blank\" rel=\"noopener\">(Download PDF)<\/a><\/strong><\/li><\/ol><ol start=\"52\"><li>L.M. van Giersbergen, A. Treiber, R. Schneiter, H. Dietrich, J. Dingemanse. Inhibitory and inductive effects of rifampicin on the pharmacokinetics of bosentan in healthy subjects, <em>Clin. Pharm. Ther. <\/em><strong>2007<\/strong>, <em>81, <\/em>414-419<em>.<\/em><\/li><\/ol><ol start=\"53\"><li>H. Bolli, J. Marfurth, C. Grisostomi, C. Boss, C. Binkert, P. Hess, A. Treiber, E. Thorin, K. Morrison, S. Buchmann, D. Bur, H. Ramuz, M. Clozel, W. Fischli, T. Weller. Novel benzo-(1,4)-diazepin-2-one derivatives as endothelin receptor antagonists. <em>J. Med. <\/em><em>Chem.<\/em> <strong>2004<\/strong>, <em>47, <\/em>2776-2795<\/li><\/ol><ol start=\"54\"><li>Treiber, R. Schneiter, S. Delahaye, M. Clozel. Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. <em>J. Pharm. Exp. Ther. <\/em><strong>2004<\/strong><em>, 308<\/em>, 1121-1129.<\/li><\/ol><ol start=\"55\"><li>Koberstein, H. Aissaoui, D. Bur, M. Clozel, W. Fischli, F. Jenck, C. M\u00fcller, O. Nayler, T. Sifferlen, A.\u00a0Treiber, T. Weller. Tetrahydroisoquinolines as orexin receptor antagonists: strategies for lead optimization by solution-phase chemistry. <em>Chimia <\/em><strong>2003<\/strong><em>, 57, <\/em>270-275.<\/li><\/ol><ol start=\"56\"><li>Treiber, P.L.M. van Giersbergen, J. Dingemanse. In vivo and in vitro disposition profile of tezosentan, an intravenous dual endothelin receptor antagonist, in humans. <em>Xenobiotica<\/em> <strong>2003<\/strong>,<em> 33, <\/em>399-414.<\/li><\/ol><ol start=\"57\"><li>Rasmussen, P.H. Poulsen, A. Treiber, S. Delahaye, A. Tankisi, G.E. Cold, K. Therkelsen, A. Gjedde, J. Astrup. No influence of the endothelin receptor antagonist bosentan on basal and indomethacin-induced reduction of cerebral blood flow in pigs. <em>Acta Anaesthesiol. Scand.<\/em><em>, <\/em><strong>2003<\/strong><em>, 47 (2), <\/em>200-207.<\/li><\/ol><ol start=\"58\"><li>L.M. van Giersbergen, C. Gnerre, A. Treiber, J. Dingemanse, U.A. Meyer. Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. <em>Eur. J. Pharmacol. <\/em><strong>2002<\/strong><em>, 450 (2), <\/em>115-121<em>.<\/em><\/li><\/ol><ol start=\"59\"><li>Treiber, P.M. Dansette, D. Mansuy. Mechanism of the aromatic hydroxylation of thiophene by acid-catalyzed peracid oxidation. <em>J. Org. Chem. <\/em><strong>2002<\/strong><em>, <\/em>67, 7261-7266<em>.<\/em><\/li><\/ol><ol start=\"60\"><li>L.M. van Giersbergen, A. Treiber, M. Clozel, F. Bodin, J. Dingemanse. In vitro and in vivo studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide. <em>Clin. Pharmacol. Ther.<\/em> <strong>2002<\/strong>, <em>71<\/em>, 253-262.<\/li><\/ol><ol start=\"61\"><li>P. M\u00e4rki, \u2026, A. Treiber, \u2026 Piperidine renin inhibitors: from leads to drug candidates. <em>Farmaco<\/em> <strong>2001<\/strong>, <em>56<\/em>, 21-27.<\/li><\/ol><ol start=\"62\"><li>T. Ho, A. Treiber, D. Mansuy, P.M. Dansette. Oxidation of 2-(4-chlorobenzoyl)-thiophene into 1-oxide Diels-Alder dimers, sesquioxide and a sulfone-water adduct. <em>Tetrahedron Letters<\/em> <strong>1998<\/strong>, <em>39<\/em>, 5049-5052.<\/li><\/ol><ol start=\"63\"><li>Treiber, P.M. Dansette, H. El Hamri, D. Ginderow, J. P. Mornon, D. Mansuy. Preparation and complete characterization of thiophene-S-oxide dimers from chemical and biological oxidation of thiophene: evidence for intermediate formation of thiophene-S-oxide in thiophene metabolism <em>in vivo<\/em> and <em>in vitro<\/em>. <em>J. Am. Chem. Soc.<\/em> <strong>1997<\/strong>, <em>119<\/em>, 1565-1571.<\/li><\/ol><ol start=\"64\"><li>Adam, R. St\u00f6ssel, A. Treiber. The S<sub>N<\/sub>2-reactivity of 3,3-disubstituted 1,2-dioxetanes with morpholine. <em>J. Org. Chem.<\/em> <strong>1995<\/strong>, <em>60<\/em>, 2879-2884.<\/li><\/ol><ol start=\"65\"><li>Adam, A. Treiber. Oxidation of acetylated guanosine by 3,3-disubstituted 1,2-dioxetanes through nucleophilic attack on the peroxide bond: model studies on the oxidative DNA damage by reactive peroxides<em>. J. Am. Chem. Soc.<\/em> <strong>1995<\/strong>, <em>117<\/em>, 2686-2693.<\/li><\/ol><ol start=\"66\"><li>Adam, L. Hadjiarapoglou, K. Mielke, A. Treiber. Competitive epoxidation and quinone formation in the dimethyldioxirane oxidation of diazoquinones as ambident nucleophiles. <em>Tetrahedron Letters<\/em> <strong>1994<\/strong>, <em>35<\/em>, 5625-5628.<\/li><\/ol><ol start=\"67\"><li>Adam, H. M. Harrer, A. Treiber. Synthesis of 1,4-dioxa-2l<sup>5<\/sup>-phosphorinanes by insertion of triphenylalkylidene phosphoranes into the peroxide bond of 1,2-dioxetanes: thermolysis, hydrolysis and Wittig olefination. <em>J. Am. Chem. Soc.<\/em> <strong>1994<\/strong>, <em>116<\/em>, 7581-7587.<\/li><\/ol><ol start=\"68\"><li>Adam, A. Treiber. 1,3-Dioxolane formation by nucleophilic attack of diazoalkanes on the peroxide bond of 1,2-dioxetanes<em>. J. Org. Chem.<\/em><strong>1994<\/strong>, <em>59<\/em>, 840-844.<\/li><\/ol><p style=\"font-weight: 400;\"><strong>\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-856fed0 e-con-full e-flex e-con e-child\" data-id=\"856fed0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4d3a798 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-parent\" data-id=\"4d3a798\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c071bd2 e-con-full e-flex e-con e-parent\" data-id=\"c071bd2\" data-element_type=\"container\" id=\"regulatory-resources\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1a3e6ea e-con-full e-flex e-con e-child\" data-id=\"1a3e6ea\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-e01faf9 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"e01faf9\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3389825 elementor-widget elementor-widget-heading\" data-id=\"3389825\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Regulatory Resources<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1435fe4 e-con-full elementor-hidden-mobile e-flex e-con e-child\" data-id=\"1435fe4\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0fb3d1 e-con-full e-flex e-con e-child\" data-id=\"c0fb3d1\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-89a11aa e-grid e-con-full e-con e-child\" data-id=\"89a11aa\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-50ac225 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"50ac225\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t<div class=\"elementor-element elementor-element-05d45ea e-con-full e-flex e-con e-child\" data-id=\"05d45ea\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9e6f9f7 elementor-widget elementor-widget-heading\" data-id=\"9e6f9f7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">ICH<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5045a53 elementor-widget elementor-widget-text-editor\" data-id=\"5045a53\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Non-clinical safety studies for the conduct of human trials: <a href=\"https:\/\/www.ema.europa.eu\/en\/ich-m3-r2-non-clinical-safety-studies-conduct-human-clinical-trials-pharmaceuticals-scientific-guideline\" target=\"_blank\" rel=\"noopener\"><strong>ICH M3 (R2)<\/strong><\/a><\/p><p>Drug-drug interactions: <strong><a href=\"https:\/\/www.ema.europa.eu\/en\/ich-m12-drug-interaction-studies-scientific-guideline\" target=\"_blank\" rel=\"noopener\">ICH M12<\/a><\/strong><\/p><p>Bioanalytical method development: <a href=\"https:\/\/www.ema.europa.eu\/en\/ich-m10-bioanalytical-method-validation-scientific-guideline\" target=\"_blank\" rel=\"noopener\"><strong>ICH M10<\/strong><\/a><\/p><p>Toxicokinetics: <a href=\"https:\/\/www.ema.europa.eu\/en\/ich-s3a-toxicokinetics-assessment-systemic-exposure-toxicity-studies-questions-answers-scientific-guideline\" target=\"_blank\" rel=\"noopener\"><strong>ICH S3A<\/strong><\/a><\/p><p>Non-clinical evaluation of anticancer drugs: <a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/s9-nonclinical-evaluation-anticancer-pharmaceuticals\" target=\"_blank\" rel=\"noopener\"><strong>ICH S9<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ac1422 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"9ac1422\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f53e25f elementor-widget elementor-widget-heading\" data-id=\"f53e25f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">FDA<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4bfbe24 elementor-widget elementor-widget-text-editor\" data-id=\"4bfbe24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Safety testing of drug metabolites: <strong><a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/safety-testing-drug-metabolites\" target=\"_blank\" rel=\"noopener\">MIST guideline<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/clinical-pharmacology-considerations-human-radiolabeled-mass-balance-studies\" target=\"_blank\" rel=\"noopener\">Human ADME studies<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/estimating-maximum-safe-starting-dose-initial-clinical-trials-therapeutics-adult-healthy-volunteers\" target=\"_blank\" rel=\"noopener\">Human starting dose<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/drug-induced-liver-injury-premarketing-clinical-evaluation\" target=\"_blank\" rel=\"noopener\">Drug-induced liver injury<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/physiologically-based-pharmacokinetic-analyses-format-and-content-guidance-industry\" target=\"_blank\" rel=\"noopener\">PBPK modelling<\/a><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-39dbf12 e-con-full animated-fast e-flex elementor-invisible e-con e-child\" data-id=\"39dbf12\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t<div class=\"elementor-element elementor-element-74a8682 e-con-full e-flex e-con e-child\" data-id=\"74a8682\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-92091c1 elementor-widget elementor-widget-heading\" data-id=\"92091c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">EMA<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38550a4 elementor-widget elementor-widget-text-editor\" data-id=\"38550a4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-strategies-identify-and-mitigate-risks-first-human-and-early-clinical-trials-investigational-medicinal-products-revision-1_en.pdf\" target=\"_blank\" rel=\"noopener\">First-in-man clinical trials<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-reporting-physiologically-based-pharmacokinetic-pbpk-modelling-and-simulation_en.pdf\" target=\"_blank\" rel=\"noopener\">PBPK modelling<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-use-pharmacogenetic-methodologies-pharmacokinetic-evaluation-medicinal-products_en.pdf\" target=\"_blank\" rel=\"noopener\">Pharmacogenomics<\/a><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Expert DMPK Consulting for Streamlined Drug Discovery and Development. Contact ADMEDDICON \u2013 DMPK Consulting is an independent preclinical consulting firm supporting biotech start-ups, university spin-offs and venture capitalists in bringing their assets from discovery into clinical stage development. 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